2025 Mercedes-Benz E350 Specs

1 powertrain configuration on federal record for the 2025 Mercedes-Benz E350: 2.0L 4-cyl Premium Gasoline, rated up to 28 MPG combined by the EPA.

Source: EPA federal records (fueleconomy.gov) · Updated 2026-10-26 · By CarWhere Research

2025 Mercedes-Benz E350 engines, transmissions, drivetrains and EPA gas mileage
EngineTransmissionDrivetrainCityHighwayCombined
2.0L 4-cyl Premium GasolineAutomatic 9-spdRear-Wheel Drive253328

E350 by year

Shopping this E350? See the market, not just the specs.

Browse live E350 inventory, see what buyers actually paid before you talk numbers.

Frequently asked questions

What engines does the 2025 Mercedes-Benz E350 have?

One powertrain on federal record: 2.0L 4-cyl Premium Gasoline, offered with Automatic 9-spd and Rear-Wheel Drive. The full per-configuration table is above.

What gas mileage does the 2025 Mercedes-Benz E350 get?

EPA combined ratings run 28–28 MPG depending on configuration — the table above shows city/highway/combined for each engine, transmission, and drivetrain.

Is 2025 a good year for the Mercedes-Benz E350?

Specs don't answer that — the federal complaint and recall record does. See the Mercedes-Benz E350 year-by-year reliability verdicts at carwhere.com/research/years-to-avoid/mercedes-benz/e350, built from NHTSA data.

How do I get the specs for my exact VIN?

These are the federal-record configurations for the 2025 Mercedes-Benz E350 overall. For one specific vehicle — its exact engine, trim, factory options, and original window sticker — decode the 17-character VIN free at carwhere.com/tools/vin-decoder.

Where does this data come from?

The U.S. EPA's public vehicle dataset (fueleconomy.gov) — the federal record of every US-market configuration since 1984 — refreshed 2026-10-26. Public-domain data; republish with attribution to CarWhere (carwhere.com).