2006 Mercedes-Benz S600 Specs

1 powertrain configuration on federal record for the 2006 Mercedes-Benz S600: 5.5L 12-cyl Premium Gasoline, rated up to 13 MPG combined by the EPA.

Source: EPA federal records (fueleconomy.gov) · Updated 2026-10-26 · By CarWhere Research

2006 Mercedes-Benz S600 engines, transmissions, drivetrains and EPA gas mileage
EngineTransmissionDrivetrainCityHighwayCombined
5.5L 12-cyl Premium GasolineAutomatic 5-spdRear-Wheel Drive111713

S600 by year

Buying a used S600? Specs are the easy half.

then check the specific car: the Full VIN Report shows that VIN's factory build, recall record, and market history before you pay for it.

Frequently asked questions

What engines does the 2006 Mercedes-Benz S600 have?

One powertrain on federal record: 5.5L 12-cyl Premium Gasoline, offered with Automatic 5-spd and Rear-Wheel Drive. The full per-configuration table is above.

What gas mileage does the 2006 Mercedes-Benz S600 get?

EPA combined ratings run 13–13 MPG depending on configuration — the table above shows city/highway/combined for each engine, transmission, and drivetrain.

How do I get the specs for my exact VIN?

These are the federal-record configurations for the 2006 Mercedes-Benz S600 overall. For one specific vehicle — its exact engine, trim, factory options, and original window sticker — decode the 17-character VIN free at carwhere.com/tools/vin-decoder.

Where does this data come from?

The U.S. EPA's public vehicle dataset (fueleconomy.gov) — the federal record of every US-market configuration since 1984 — refreshed 2026-10-26. Public-domain data; republish with attribution to CarWhere (carwhere.com).